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Author information: John's wort Hypericum perforatum, SJW is one of the most commonly used scrsening antidepressants for the treatment of minor to moderate depression. Limited clinical Free drug screening Sarpsborg suggest that hypericum and standard antidepressants have similar beneficial effects, but current evidence regarding the antidepression effects of SJW extracts is inconsistent. This review highlights and updates the knowledge regarding drug interactions with SJW by a systematic review of all the available evidence, including worldwide published literature and spontaneous screenung reports. A number of clinically significant interactions of SJW Sweet Arendal sex been identified with conventional drugs. These interactions often result in a decrease in the concentration or effect of the combined drug, most probably due to the induction of cytochrome Ps CYPs and the key drug transporter P-glycoprotein P-gp by the major active Sarpsboorg in SJW.

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